The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly.
Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein complex at the RBC surface.This virulence-mediating structure, called the knob, acts as a scaffold for the presentation of the major virulence antigen, P.falciparum Erythrocyte Membrane Protein-1 (PfEMP1).In this work we de